BSRA 75th ASM: Oxford

With thanks to our session sponsors, BBSRC

Communicating the Value of Ageing Research

Led by professionals from Fieldcraft Communications, and chaired by BSRA Chair Prof David Weinkove, this workshop will focus on telling the story of your research: what stories to tell, how to tell them and why it's so important. Tailored specifically for early career researchers, but open to all.

ECR presentations from:

David Weinkove, Chair BSRA

Vice-Chancellor's representative, University of Oxford

Ira Milosevic, BSRA local organiser

Session Chair: Paul Shiels, University of Glasgow

With thanks to our session sponsors, Wiley International:

Session Chair: Ghada Alsaleh, University of Oxford:

Colin Selman (UK): Genetic Pathways to a Longer, Healthier Life: Lessons from RNA Polymerase III in Mice

Mirre Simons (UK): Suppression rather than activation of the integrated stress response (GCN2–ATF4) pathway extends lifespan in the fly

Emily Print (UK): Ageing Oocytes Shape the Human Mutational Landscape

Tomàs Schmauck-Medina (Norway): ATG-18 drives longevity in an HLH-30 dependent manner

Guang-Hui Liu (China): From Basic Discovery to Healthy Ageing

Chair: Bradley Elliott

Panellists: Elizabeth Mills OBE, David Gems, TBC

Session chair: Paul Morgan, Manchester Metropolitan University

Coordinators: Paul Morgan (BSRA/Manchester Metropolitan University), Thibaud Martial (University of Oxford)

Session Chair: Jon Houseley, Babraham Institute

Marco Demaria (Netherlands): Pro-inflammatory functions of Purinergic signaling in Cellular Senescence

Maria Kyriazi (UK): TFEB-mediated autophagy might protect against age-related joint damage and osteoarthritis

Neuza Domingues (Portugal): Nuclear Lysosomes: lysosomal CLN3 role in nuclear ageing phenotypes

David Gems (UK): Slow Gompertzian aging in long-lived C. elegans results from expansion of decrepitude, not decelerated aging

KJ Patel (Oxford, UK): Endogenous formaldehyde stimulates accelerated ageing in humans and mice

Session Chair: James Murray, Swansea University

Ana Maria Cuervo (USA): Selective Autophagy: promoting healthy aging one protein at a time

Joris Deelen (Netherlands): Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

Ana Caulino (Portugal): Endophilin-A–FBXO32 Interaction restores proteostatic balance and dopaminergic function in accelerated brain ageing

Helen Jolly (UK): Moving beyond abundance: Proteome-wide characterisation of localisation change in Alzheimer's disease and cognitive resilience

Dag Aarsland (UK): Dementia Risk in the Community: from lifestyle interventions for prevention to biomarkers and therapeutics

Chair: Nuno Raimundo, Penn State College of Medecine, US

Panellists: Danny Arends (Northumbria University), Fedor Galkin (Insilico Medicine), Daniel Muñoz Espín (University of Cambridge)

Session Chair: Charamlampos (Babis) Rallis, Queen Mary University)

Nuno Raimondo (US): E Pluribus unum: How organelle crosstalk shapes cellular aging

Timothy Rhoads (US): Splicing factor engagement and regulation of RNA processing during caloric restriction

Matteo Forte (Australia): Using nutrient interactions to uncover the nutritional and signalling requirements to sustain life in Drosophila melanogaster

Laurence Maeyens (US): Adipose Tissue Quality as a Driver of the Male Longevity Disadvantage

Maria Ermolaeva (Germany): Metabolic plasticity as both driver and constraint of healthy aging

Session Chair: Ira Milosevic, University of Oxford

Dr David Cox will be presenting his book, The Age Code

Reading, discussion and signing

Session Chair: Laura Sinclair, University of Exeter

Danny Arends (UK): Dynamics of genetic and somatic trade-offs in ageing and mortality

Julio Zarazua (UK): Photobiomodulation 1068 nm in normal ageing and neurodegenerative diseases

Zheng Liang (UK): Conserved innate immunity pathways in Nothobranchius furzeri

Satomi Miwa (UK): Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity substances

Kevin Perez (Switzerland): A Cross-Species Drug-Discovery Platform to Accelerate the Identification of Lifespan-Extending Interventions

Fedor Galkin (USA): Assessing geroprotector potential of AI-designed drugs in clinical trials

Session Chair: Ira Milosevic, University of Oxford

John Hardy (UK): Progress towards therapies of the neurodegenerative diseases

Della David (UK): Identification of a novel human extracellular chaperone promoting healthy ageing

Izaak Myatt (UK): AMPK-dependent functional remodelling of senescent human microglia occurs independently of mTORC1 activation

Nada Abdul Jaleel (UK): Extended Fasting Modulates Urinary Proteomic Signatures Associated with Healthy Ageing and Neurodegenerative Pathways

Anne Schaefer (Germany): Innate control of neuroinflammation and cognition by microglia

Chair: David Weinkove, Durham University

Panellists: Pablo Cabral (Eli Lilly), Laura Sinclair (Exeter), Anne McArdle (Liverpool)

Session Chair: Jonathan Lewis, Birmingham University

Early Career Researcher pitch presentations from:

• Loren Kell (UK)
• Bhavnesh Bishnoi (India)
• Kaixin Zhang (UK)
• Isabelle Foote (UK)
• Lee Butcher (UK)
• Taylor McGilvary (UK)
• Sofia Fereire (Portugal)
• Peter Brederlow (UK)

Session Chair: Paul Potter, Oxford Brookes University

Daniel Muñoz Espín (Spain): Targeting Senescent Tumour Microenvironments in Lung Cancer and Ageing for Precision Medicine

Helena Aires (Portugal): Nanoparticle-Induced Elimination of Senescent Cells via Lysosomal Disruption

Declan Moran (UK): Leveraging Spaceflight to Accelerate Biological Ageing and Geroprotective Drug Discovery in Human-Derived Organoids

Nicole Wojtania (UK): Nanoparticle-mediated protein degradation as a senotherapeutic

Patrick Gunning (UK): Plasma proteomic platform and our initial findings

Announcement of the Korenchevsky Prize winner and winners of the poster prizes, by BSRA Chair, David Weinkove