- Chair: Prof. Dr. Michael Müller
- Welcome address by Prof. Dr. Lutz Hein

Sustainability as a Challenge for the Pharmaceutical Sciences

From Phamaceuticals in the Environment to Greener Pharmacy and more Sustainable Pharmacy
- Chairs: Prof. Dr. Dagmar Fischer, Prof. Dr. Peter Langguth

Sustainable Strategies to contain antimicrobial resistance
- Chairs: Dr. Gesche Först, Prof. Dr. Anna Hirsch

11:00 Dr. Alexandra Weber (München)
Penicillin allergy delabeling

11:30 Prof. Dr. Alexander Harms (Zürich)
Viruses against superbugs: Bacteriophage therapy from bedside to bench and back

12:00 Dr. Adrian Richter (Halle)
Synthesis and Characterization of RNA Polymerase and ATP Synthase Inhibitors with Activity Against Resistant Mycobacteria

12:15 Nicole Zimmermann (Berlin)
Regrowth dynamics play an important role for the antibacterial effect of fosfomycin and amikacin in mono- and combination therapy against Escherichia coli

Chair: Dr. Laurine Kaul

List of Flash Talks

Novel strategies in nucleic acid therapeutics: genome editing and beyond
- Chairs: Prof. Dr. Achim Aigner

11:00 Prof. Dr. Toni Cathomen (Freiburg)
From Gene to Market: Genome Editing as a Therapeutic Reality

11:25 Prof. Dr. Zoltán Ivics (Leipzig)
Genetic engineering of therapeutic cells: Challenges and Solutions

11:50 Prof. Dr. Satoshi Obika (Osaka, Japan)
Development of nucleic acid derivatives for application in oligonucleotide therapeutics

12:15 Tristan Dewald (Mainz)
Development of RNA-based PROTACs as a strategy for targeting RNA-modifying enzymes

Chemical Epigenetics
- Chairs: Prof. Dr. Cristina Nevado, Prof. Dr. Manfred Jung

11:00 Dr. Martin Schröder (Basel)
Expanding the ligase and target space of targeted protein degradation

11:25 Prof. Dr. Finn Hansen
Development of Ethyl Hydrazide-Based Histone Deacetylase Inhibitors and Degraders to Combat Chemoresistance in Cancer

11:45 Nicolas Heller, Prof. Dr. Manfred Jung (Freiburg)
Structure-based Development and Synthesis of Lysine Methyltransferase Inhibitors

12:00 Dr. Katherine Gosselé, Prof. Dr. Cristina Nevado (Zürich)
BAZ2A/B….the journey towards selective degraders

12:15 Dr. Christian Steinebach (Bonn)
Leveraging induced proximity modalities for drugging epigenetic proteins

Careers in Pharma: From Campus to Industry or Health Authorities
Get insights from early carreer professionals and experienced pharma leaders - and join the conversation

- Moderators: Dr. Reinhold Rößler

Expert Panel:
Federica Albissola, Regulatory Affairs Consultant
Dr. Sarah David, Novartis AG
Prof. Dr. Werner Knöss, Federal Institute for Drugs and Medical Devices (BfArM)
Dr. Jörg Schlingemann , Merck Healthcare KGaA
Dr. Hendrik von Büren , Retired Managing Director R&D, AbbVie

Rethinking antivirals
- Chairs: Prof. Dr. Christian Klein, Prof. Dr. Wibke Diederich

14:00 Prof. Dr. Arnold Grünweller (Marburg)
Being prepared - Targeting the host factor eIF4A as a pan-antiviral therapeutic strategy

14:25 Prof. Dr. Anna Hirsch (Saarbrücken)
Multiparameter optimisation of novel respiratory syncytial virus inhibitors targeting the F-protein

14:50 Dr. Christopher Veeck (Marburg)
Rethinking Antiviral Therapy: Exploring Targeted Protein Degradation as a Novel Antiviral Strategy

15:15 Dr. Thanigaimalai Pillaiyar (Tübingen)
Efficacy and structural insights of covalent dipeptide inhibitors on drug-resistant SARS-CoV-2 Mpro mutants

Natural products from plants, fungi and microorganisms
- Chairs: Prof. Dr. Andreas Bechthold, Prof. Dr. Gunhild Layer 

14:00 Prof. Dr. Simone Moser (Innsbruck)
From waste to value - exploiting plant senescence for natural products research

14:30 Prof. Dr. Ludger Beerhues (Braunschweig)
Biotechnology of hyperforin-like natural products for drug development

15:00 Prof. Dr. Silja Mordhorst (Tübingen)
Exploring bacterial natural products as a source of novel bioactive compounds

15:15 Dr. Karin Bartel (München)
Endolysosomal ion channels TPC2 and TRPML1 as promising anti-cancer targets

Scope and limits of drug recovery from altar chemicals and the environment
- Moderators: Prof. Dr. Michael Müller, Dr. Karina Witte

14:00 Short Presentations
Prof. Dr. Markus Heinrich (Erlangen)
Practical Examples of Pharmaceutical Waste Processing 
Johanna Greinke (Freiburg)
PFAS/TFA Challenges: Risks and Solutions

14:30 Pub quiz

15:00 Interactive work in smaller groups

- Pharmaceutical & Medicinal Chemistry: Hörsaal Rundbau
- Industrial Pharmacy: Hörsaal Chemie
- Pharmacology and Toxicology: Hörsaal Otto-Krayer-Haus
- Pharmaceutical Technology and Biopharmaceutics: PI - Seminarraum R 00 018 
- Clinical Pharmacy: PI - Seminarraum R 00 019/020
- Radiopharmacy: On Wednesday, directly after the Radiopharmacy session

Guided tour: 16.45-17.45, followed by free strolling

Targeting the “undruggable": An RNA binding protein connecting tumor cells and the tumor microenvironment
- Chairs: Prof. Dr. Gregor Fuhrmann,  Prof. Dr. Claudia Jessen-Trefzer

For DPhG-members only

New Research, New Researchers
- Chairs: Dr. Kerstin Hiesinger, Dr. Wenxin Felix Zhu

9:00 Wiebke Fiebiger (Halle)
A novel tool to investigate inflammation-driven carcinogenesis: Modeling colorectal carcinoma in thromboxane receptor-deficient mice

9:15 Bernadette Vallaster  (Regensburg)
Assessment of covalent warhead reactivity heading towards druggable small molecule Caspase-2 inhibitors

9:30 Jana Haegner (Braunschweig)
Affinity Capillary Electrophoresis (ACE) as a Label-Free Binding Assay for Membrane Proteins: Application on CXCR2

9:45 Clemens Woitaske-Proske (Kiel)
Concept for the implementation of an environmental information, classification and dissemination system in Germany (“Arzneimittelindex Umwelt”)

10:00 Prof. Dr. Radosław Nowak (Bonn)
Targeting oncogenic transcription factors with small molecules

Sustainable drug carriers – from biological nanoparticles to natural polymers
- Chairs: Prof. Dr. Dagmar Fischer, Prof. Dr. Gregor Fuhrmann

9:00 Prof. Dr. Dagmar Fischer (Erlangen)
Bacteria help to heal – Drug delivery systems from bacteria for inflammation and infection

9:30 Dr. Andrea Zendrini (Zürich, Brescia)
Engineered Red Blood Cells-derived Vesicles for Synergistic Chemotherapy

10:00 Maria Krabbes (Leipzig)
Development of lipoplex-loaded biopolymer films as a local nucleic acid delivering wound dressing

10:15 Veronika Grassl (Erlangen)
A Library of Green and Sustainable Solvents for the Preparation of PLGA Nanoparticles Containing the Lipophilic Drug 6BIGOE

Cellular mechanisms – from understanding diseases to the development of ATMPs
- Chairs: Prof. Dr. Martin Hug, Prof. Dr. Hanna Seidling

9:00 Prof. Dr. Julia Stingl (Heidelberg)
ATMPs – what’s new from a regulatory perspective

9:30 Prof. Dr. Itsuko Ishii (Chiba, Japan)
Acrolein-modified lipoproteins influence on development of atherosclerosis

10:00 Fenja Klima (Berlin)
Model-informed CAR-T sampling strategies for efficient and robust clinical study designs: Towards better understanding of cancer immunotherapies

10:15 Sandra Witta, Hamburg
Towards Model-Informed Precision Dosing of Busulfan: An External Model Evaluation

Pharmacy and Crime
- Chairs: Prof. Dr. Marcus Plehn, Prof. Dr. Axel Helmstädter

9:00 Dr. Helena Barop (Freiburg)
Aus der Drogerie in den Giftschrank und zurück: Die (Ent-)Kriminalisierung von Cannabis

10:00 Dr. Marcus Carrier (Berlin)
Toxic! Chemical Analyses and Poisoning Trials in the 19th Century

Harnessing Medicinal Chemistry for Sustainable New Drugs
- Chairs: Prof. Dr. Bernhard Wünsch, Prof. Dr. Stefan Laufer

Sustainability meets innovation: Radiopharmacy between environmental awareness and modern tumor diagnostics
- Chairs: Prof. Dr. Sarah Spreckelmeyer, Prof. Dr. Andreas Maurer 

14:00 Assoz. Prof. Mag. Dr. Verena Pichler (Wien)
Sustainability in pharmaceutical sciences: Green principles of radiopharmacy

14:25 PD Dr. Mark Bartholomä (Homburg)
Delayed PET Imaging of metastatic, castration-resistent prostate cancer using longer-lived radionuclides

14:50 Prof. Dr. Bernd Neumaier (Köln, Jülich)
Production and isolation of astatine-211 for clinical applications

15:15 Punita Bhardwaj (Berlin)
Synthesis and Biological Evaluation of [198Au]Auranofin and 198Au-radiolabeled precursors in comparison to their non-radioactive counterparts

GLP-1 receptor agonists - more than antidiabetic therapy
- Chairs: Prof. Dr. Martina Düfer, Prof. Dr. Moritz Bünemann

14:00 Dr. Ralf Jockers (Paris)
How to rescue natural GLP-1R variants associated with impaired glucose control and increased adiposity

14:30 Dr. Johannes Broichhagen (Berlin)
Chemical Biology Probes Targeting the GLP1 Receptor

15:00 Dr. Sabine Willems (Sweden)
A chemogenomic approach to target identification in a primary human MASH model

15:15 Dr. Jorge Duque Escobar (Lübeck)
CRIP1 and the NLRP3 Inflammasome: A Silent Regulator Linking Inflammation to Hypertension?

Applications of nucleic acids and the technologies beyond
- Chairs: Dr. Laurine Kaul, Prof. Dr. Thomas Winckler

14:00 Prof. Dr. Ulrich Lächelt (Wien)
Synthetic delivery systems for nucleic acids and CRISPR/Cas genome editing

14:30 Dr. Benedikt Kirchner
Unfortunately, the talk has to be canceled at short notice.

15:00 Dr. Philipp König (Bonn)
Tackling Resistance to PARP-Inhibitors in Ovarian Cancer: The Role of DNA Repair Pathways and the Extracellular Matrix

15:15 Julia Leisel (Erlangen)
Tailored Design of Guanidinium-Functionalized Methacrylamides for Gene Delivery by Controlling Their Hydrophilic / Hydrophobic Balance

Analytics, data, digitalization
- Chairs: Prof. Dr. Hermann Wätzig, Prof. Dr. Maria Kristina Parr

14:00 Prof. Dr. Oliver Koch (Münster)
AI in Pharmaceutical Sciences: Let's talk about data

14:30 Marlon Krompholz (Braunschweig)
AI-powered Peak Integration - Mastering quantitative analysis in separation sciences

15:00 Marius Amann (Freiburg)
Computational Protein Design Enables Stabilization and Biophysical Characterization of Plasmodium falciparum Drug Targets for Drug Discovery

15:15 Claudia Stärk (Bonn)
Development of a monograph draft for lipid excipients in lipid nanoparticles used in mRNA vaccines

Jointly organized with the Bundesverband der Pharmaziestudierenden in Deutschland (BPhD)

Promovieren - Wie, wo und warum?
- Moderator: Prof. Dr. Ulrich Jaehde
- BPhD: Christiane Donat und Anna Jonas

Members' meeting of the working group Radiopharmacy

From Fasting to Wasting: Molecular Checkpoints in Obesity and Cancer
- Chairs: Prof. Dr. Elke Oetjen, Prof. Dr. Norbert Klugbauer 

Highlights in GPCR and nuclear receptor research
- Chairs: Prof. Dr. Matthias Schiedel, Dr. Dorothée Weikert 

16:45 Prof. Dr. Steffen Pockes (Regensburg)
Discovery of GPR3 ligands by combined virtual and conformational biosensor-based screening

17:10 Dr. Dorothée Weikert (Erlangen-Nürnberg)
Unlocking bitter taste: Ligand recognition by the bitter taste receptor TAS2R14

17:35 Prof. Dr. Bernhard Wünsch (Münster)
Bridged piperidines and piperazines as conformationally restricted kappa-opioid receptor agonists

18:00 Dr. Pascal Heitel (Frankfurt)
Scaffold Hopping Provides Subtype-selective Liver X Receptor Beta Agonists

Antibody-drug conjugates (ADC) - Advances and potential in tumor therapy
- Chairs: Prof. Dr. Achim Aigner, Prof. Dr. Raphael Reuten

16:45 Prof. Dr. Achim Aigner (Leipzig)
Antibody Drug Conjugates (ADCs): From Mechanisms of Action to Challenges and Perspectives

17:10 Prof. Dr. Michael Quante (Freiburg)
Antibody Drug Conjugate (ADC): Precision Medicine for Gastrointestinal Tumors

17:35 Prof. Dr. Christian Hackenberger (Berlin)
P5-labeling for generating highly efficacious antibody-conjugates for cancer therapy 

18:00 Corinna Weiler (Bonn)
Active disruption of GPCR-G protein interaction at the interface with a small molecule

Innovative strategies in the industrial development and life cycle of complex drugs – technological, analytical, and regulatory aspects
Chair: Dr. Reinhold Rößler, Dr. Hendrik von Büren 

16:45 Dr. Joachim Herrmann (Karlsruhe)
Pharmaceutical innovations for Herbal Medicinal Products - Opportunities and limitations

17:15 Dr. Jörg Schlingemann (Darmstadt)
The Nitrosamine Saga

17:45 Prof. Dr. Werner Knöss (Bonn)
Pharmaceutical quality in development and life cycle of medicinal products – today´s requirements and future needs

Adaptation of drug therapy during hot seasons
Unfortunately, the workshop has to be canceled at short notice.

Registration required

Please note that this is not the official entrance to the market hall. Please use the side entrance at the following address: 

Markthalle Freiburg 
Kaiser-Joseph-Straße 237
79098 Freiburg im Breisgau

Sustainability in Pharmaceutical Analysis
- Chair: Prof. Dr. Maria Kristina Parr, Prof. Dr. Ann Van Schepdael

9:00 Prof. Dr. Ann Van Schepdael (Leuven)
Capillary electrophoresis as a sustainable analytical tool for drug discovery and development

9:25 Dr. Andreas Otto (Waldbronn)
Transparency and Awareness: Key Drivers of Sustainability in Laboratory Environments

9:50 Dr. Felix Bredendiek (Berlin)
Sustainability in practice: challenges and solutions in the nitrosamine testing procedure

10:15 Dr. Banaz Jalil (London)
Does climate change impact the phytochemical quality of medicinal and aromatic plants? A case study of Lavandula species products

Gastro-intestinal drug contents and drug product performance
- Chairs: Prof. Dr. Peter Langguth, Prof. Dr. Werner Weitschies

9:00 Dr. Mirko Koziolek (Ludwigshafen)
The composition of human intestinal fluids and its impact on oral drug delivery

9:25 Dr. Linus Großmann (Greifswald)
Real-time Magnetic Resonance Imaging: An Innovative Tool for Biopharmaceutical Research

9:50 Valentin Stahl (Mainz)
Determination of drug release from tablets in viscous media

10:15 Prof. Dr. Philipp Uhl (Heidelberg)
Unfortunately, the talk has to be canceled at short notice.

Pharmaceutical Sciences in Freiburg
- Chairs: Prof. Dr. Jennifer Andexer, Prof. Dr. Manfred Jung

9:00 Prof. Dr. Jennifer Andexer (Freiburg)
Pharmaceutical Sciences in Freiburg

9:15 Dr. Laurine Kaul (Freiburg)
Targeted Degradation on Demand: Advancing PROTAC Delivery via Nanotechnology

9:40 Dr. Nico Fessner (Freiburg)
First Aid Kit for Medicinal Chemists: Enzymatic late-stage Functionalisation of Natural Products

10:05 Dr. Gesche Först (Freiburg)
Data-Driven Antimicrobial Stewardship: Turning Insight into Impact

How to write a DFG grant application
- Moderation: Dr. Torsten Hotopp, Prof. Dr. Michaela Schulz-Siegmund

9:00-9:30: Dr. Torsten Hotopp (Bonn)

Presentations by Successful Applicants for DFG Funding:
- Prof. Dr. Christa E. Müller (Bonn)
- Prof. Dr. Miriam Breunig (Regensburg)

Discussion with the Speakers and Elected Members of the DFG Review Board (Prof. Dr. Stefan Laufer (Tübingen), Prof. Dr. Bernd Neumaier (Jülich, Köln) Prof. Dr. Michaela Schulz-Siegmund (Leipzig)).

Shaping the future of pharmacy with pharmacogenetics research and implementation
- Chairs: Dr. Gesche Först, Prof. Dr. Oliver Scherf-Clavel